Testing for EDDP and Methadone

What is Methadone?

Methadone is an oral substitute for heroin and other morphine-like drugs. It is a synthetic opiate that is commonly administered in detoxification programs to suppress withdrawal symptoms and/or to maintain drug takers that are chronically addicted to heroin.

What is EDDP?

EDDP is the molecule obtained after the human body has modified the basic molecule of Methadone in order to eliminate it. It is this metabolite that can be found in urine.

The advantage of testing for EDDP instead of methadone (MTD) is that individuals in methadone programs may pass off their methadone into the illegal drug market and then try and hide this activity by putting a few drops of methadone into their urine sample. This type of activity is known as “spiking.” In these situations the urine sample will contain large amounts of methadone and no or insignificant amounts of EDDP. This is because the drug was not ingested and therefore not metabolised. Testing for EDDP will help identify any attempts to cheat the test.

What is the cut-off for an EDDP drug test?

The cut-off for this EDDP tests is 100 ng/ml. A positive test result will be given if the urine sample contains at least 100 nanograms of EDDP per millilitre of urine. A negative reading will be the result if the sample contains less than that.

For how long can EDDP be detected in urine?

Detection time of EDDP in urine is normally 3 to 4 days after consumption.

EDDP Urine Drug Test

The Zoom Testing EDDP urine drug test is supplied for healthcare professional use and provides preliminary screening results.  Zoom Testing recommends that a more specific chemical method (i.e. GC/MS) be used in order to obtain a confirmed analytical result.

Photo Credit: “Methadone” (CC BY 2.0) by THRILLHO